A research read on the peptides currently studied for longevity outcomes - rapamycin, NAD+, MOTS-c, GHK-Cu, Klotho, epitalon, GHRH analogs, and the rest. Which have human evidence, which have only model-organism data, and what each actually does at the mechanism level.
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Sara Vance
Peptide research & literature
About
Sara writes the peptide guides, the mechanism explainers, and the research-literature reviews. Her background is in pharmacology research — eight years at a contract research organization running preclinical pharmacokinetics work before moving into science writing full-time. She reads the primary research literature so vialaudit readers don't have to, and she's the person on the desk who decides which peptide is mature enough for a guide. If a compound only has rodent data, she says so. If a Phase 2 trial is being misrepresented in community discussion, she writes the literature read. Sara writes under a pen name. The peptide research-protocol space attracts strong opinions and direct outreach to authors; she'd rather keep the email volume manageable and the work honest.
Topic specialty
Peptide guides, mechanism explainers, primary-literature reviews, pharmacokinetics summaries, dose-research literature, trial result reads.
Bibliography
KLOW is a four-component peptide stack growing fast in research-protocol discussion. Here's the literature read - what each compound does, what the mechanism overlap argues, and what's actually been studied as a combination.
BPC-157 and TB-500 are the most-stacked combination in research-peptide protocols. The compounds work through different mechanisms — angiogenesis vs actin sequestration — which is why the combination is studied. Here's the literature read.
TRIUMPH Phase 3 dose-titration schedule — 2 mg start, 4-week steps up to 12 mg weekly maintenance — with full literature read of the maintenance doses and tolerability protocols from Eli Lilly's published retatrutide trials. Not human-use guidance; regulatory state in May 2026 is Phase 3, no FDA approval.
GI events (nausea ~50% at high dose, vomiting, diarrhea) plus a 1–3 bpm heart-rate signal attributed to glucagon-receptor activity — the literature read of side-effect frequencies from the published Phase 2 and TRIUMPH Phase 3 retatrutide trials, including the TRIUMPH-5 cardiovascular question still pending.
Eli Lilly's Phase 3 retatrutide program reads out across the TRIUMPH-1 through TRIUMPH-5 trials. The headline figure — ~24% mean body-weight reduction at 48 weeks — beats tirzepatide's SURMOUNT ceiling by 2–4 points. Here's what the published Phase 3 data shows, what it doesn't, and the 2026 FDA submission timeline.
Contact
Tips, corrections, or comments on research desk coverage: research@vialaudit.com