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peptide comparison · longevity × metabolic

MOTS-c vs Retatrutide

Two compounds, mechanism by mechanism. Where they overlap, where they don't, and which vendors stock each.

§ 01

Mechanism

mots-c

MOTS-c

Mitochondrial-Derived PeptideMOTS

Mitochondrial-derived peptide encoded in the 12S rRNA gene. Activates AMPK signaling and modulates metabolic adaptation. Often described as an exercise-mimetic compound.

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vs
retatrutide

Retatrutide

LY3437943GLP-3triple-G

Triple agonist of GLP-1, GIP, and glucagon receptors. Eli Lilly's Phase 3 candidate (TRIUMPH program).

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§ 02

Key facts

factMOTS-cRetatrutide
category
·longevitymetabolic·
half-life
·Not fully characterized; multi-hour systemic effects observed~6 days·
research dosing
·Research literature cites 5–15 mg subcutaneous in cycles of 2–8 weeks.Research literature cites 1–12 mg weekly subcutaneous in dose-escalation studies.·
trending
search demand
○60/10095/100●
vendors stocking
○06●
aliases
·Mitochondrial-Derived Peptide · MOTSLY3437943 · GLP-3 · triple-G·
§ 03

Use-case overlap

only mots-c
  • mitochondrial function
  • exercise-response research
  • metabolic regulation
both

none

only retatrutide
  • weight loss
  • metabolic dysfunction
  • fatty liver
§ 04

Where to buy

mots-c
MOTS-c
0 verified vendors
See all vendors →
retatrutide
Retatrutide
6 verified vendors
Ascension PeptidesLimitless Life NootropicsParadigm PeptidesPeptide Sciences+2 more
See all vendors →
§ 05

Sources

  1. [01]The mitochondrial-derived peptide MOTS-c regulates muscle metabolism — Cell Metabolism· MOTS-c
  2. [02]MOTS-c and mitochondrial communication — Trends in Endocrinology· MOTS-c
  3. [03]Triple–Hormone-Receptor Agonist Retatrutide for Obesity (NEJM)· Retatrutide
  4. [04]Lilly TRIUMPH Phase 3 announcement· Retatrutide
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