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peptide comparison · longevity × metabolic

NAD+ vs Retatrutide

Two compounds, mechanism by mechanism. Where they overlap, where they don't, and which vendors stock each.

§ 01

Mechanism

nad-plus

NAD+

Nicotinamide Adenine DinucleotideNAD

Coenzyme central to redox reactions and energy metabolism in every cell. Levels decline with age, which has driven a research interest in NAD+ supplementation as a longevity intervention.

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vs
retatrutide

Retatrutide

LY3437943GLP-3triple-G

Triple agonist of GLP-1, GIP, and glucagon receptors. Eli Lilly's Phase 3 candidate (TRIUMPH program).

Full guide →
§ 02

Key facts

factNAD+Retatrutide
category
·longevitymetabolic·
half-life
·Hours; rapidly converted intracellularly~6 days·
research dosing
·Research literature cites 100–500 mg subcutaneous or IV in protocols ranging from single-dose to weekly maintenance.Research literature cites 1–12 mg weekly subcutaneous in dose-escalation studies.·
trending
search demand
○70/10095/100●
vendors stocking
○06●
aliases
·Nicotinamide Adenine Dinucleotide · NADLY3437943 · GLP-3 · triple-G·
§ 03

Use-case overlap

only nad-plus
  • cellular energy
  • mitochondrial function
  • aging research
both

none

only retatrutide
  • weight loss
  • metabolic dysfunction
  • fatty liver
§ 04

Where to buy

nad-plus
NAD+
0 verified vendors
See all vendors →
retatrutide
Retatrutide
6 verified vendors
Ascension PeptidesLimitless Life NootropicsParadigm PeptidesPeptide Sciences+2 more
See all vendors →
§ 05

Sources

  1. [01]Therapeutic potential of NAD-boosting molecules — The Lancet Healthy Longevity· NAD+
  2. [02]NAD+ in aging, metabolism, and neurodegeneration — Science· NAD+
  3. [03]Triple–Hormone-Receptor Agonist Retatrutide for Obesity (NEJM)· Retatrutide
  4. [04]Lilly TRIUMPH Phase 3 announcement· Retatrutide
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