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peptide comparison · metabolic

Retatrutide vs Semaglutide

Two compounds, mechanism by mechanism. Where they overlap, where they don't, and which vendors stock each.

§ 01

Mechanism

retatrutide

Retatrutide

LY3437943GLP-3triple-G

Triple agonist of GLP-1, GIP, and glucagon receptors. Eli Lilly's Phase 3 candidate (TRIUMPH program).

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vs
semaglutide

Semaglutide

OzempicWegovyRybelsus

GLP-1 receptor agonist. FDA-approved as Ozempic (T2D), Wegovy (obesity), and Rybelsus (oral T2D).

Full guide →
§ 02

Key facts

factRetatrutideSemaglutide
category
·metabolicmetabolic·
half-life
·~6 days~7 days·
research dosing
·Research literature cites 1–12 mg weekly subcutaneous in dose-escalation studies.Research literature cites 0.25–2.4 mg weekly subcutaneous.·
trending
search demand
●95/10082/100○
vendors stocking
·11·
aliases
·LY3437943 · GLP-3 · triple-GOzempic · Wegovy · Rybelsus·
§ 03

Use-case overlap

only retatrutide
  • metabolic dysfunction
  • fatty liver
both
  • weight loss
only semaglutide
  • type 2 diabetes
  • cardiovascular risk reduction
§ 04

Where to buy

retatrutide
Retatrutide
1 verified vendor
Limitless Life Nootropics
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semaglutide
Semaglutide
1 verified vendor
Amino Asylum
See all vendors →
§ 05

Sources

  1. [01]Triple–Hormone-Receptor Agonist Retatrutide for Obesity (NEJM)· Retatrutide
  2. [02]Lilly TRIUMPH Phase 3 announcement· Retatrutide
  3. [03]Once-Weekly Semaglutide in Adults with Overweight or Obesity (NEJM)· Semaglutide
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