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peptide guide · metabolic · trending 82

Semaglutide

OzempicWegovyRybelsus

GLP-1 receptor agonist. FDA-approved as Ozempic (T2D), Wegovy (obesity), and Rybelsus (oral T2D).

category
metabolic
half-life
~7 days
research dosing
Research literature cites 0.25–2.4 mg weekly subcutaneous.
vendors stocking
1
§ 01

Research notes

Mechanism

Semaglutide is a long-acting GLP-1 receptor agonist developed by Novo Nordisk. It's the first compound in the modern GLP-1 weight-loss class, FDA-approved across three brand names — Ozempic, Wegovy, Rybelsus — for partly overlapping indications.

Research dosing

Standard escalation goes 0.25 → 0.5 → 1.0 → 1.7 → 2.4 mg weekly. The 2.4 mg dose is the peak per-week weight-loss target used in the STEP trials.

Vendor coverage

Semaglutide remains the best-covered compound in the research-vendor market — every audited vendor lists it. Pricing has compressed significantly through 2025–2026 as more vendors entered. Lower-tier vendors increasingly differentiate on price; top-tier vendors compete on COA quality.

§ 02

What it's researched for

  • weight loss
  • type 2 diabetes
  • cardiovascular risk reduction
§ 03

Where to source it

top 3 by compositeSee all 1 vendors →
vendor · shut down

Amino Asylum

closed

Permanently shut down June 2025 following an FDA raid. Do not order.

0/100
0d ship · last test 2026-03-28T00:00:00.000ZRead audit →
§ 04

Sources

  1. [01]Once-Weekly Semaglutide in Adults with Overweight or Obesity (NEJM)
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