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peptide comparison · metabolic × growth

Retatrutide vs Tesamorelin

Two compounds, mechanism by mechanism. Where they overlap, where they don't, and which vendors stock each.

§ 01

Mechanism

retatrutide

Retatrutide

LY3437943GLP-3triple-G

Triple agonist of GLP-1, GIP, and glucagon receptors. Eli Lilly's Phase 3 candidate (TRIUMPH program).

Full guide →
vs
tesamorelin

Tesamorelin

TH9507Egrifta

Synthetic 44-amino-acid analog of growth hormone-releasing hormone (GHRH). Stimulates pituitary release of endogenous growth hormone in a pulsatile manner.

Full guide →
§ 02

Key facts

factRetatrutideTesamorelin
category
·metabolicgrowth·
half-life
·~6 days~30 minutes (with sustained pituitary effect)·
research dosing
·Research literature cites 1–12 mg weekly subcutaneous in dose-escalation studies.Research literature cites 1–2 mg daily subcutaneous, typically administered before bed.·
trending
search demand
●95/10065/100○
vendors stocking
●60○
aliases
·LY3437943 · GLP-3 · triple-GTH9507 · Egrifta·
§ 03

Use-case overlap

only retatrutide
  • weight loss
  • metabolic dysfunction
  • fatty liver
both

none

only tesamorelin
  • visceral fat reduction
  • GHRH analog research
  • HIV-associated lipodystrophy (FDA-approved indication)
§ 04

Where to buy

retatrutide
Retatrutide
6 verified vendors
Ascension PeptidesLimitless Life NootropicsParadigm PeptidesPeptide Sciences+2 more
See all vendors →
tesamorelin
Tesamorelin
0 verified vendors
See all vendors →
§ 05

Sources

  1. [01]Triple–Hormone-Receptor Agonist Retatrutide for Obesity (NEJM)· Retatrutide
  2. [02]Lilly TRIUMPH Phase 3 announcement· Retatrutide
  3. [03]Effects of tesamorelin on visceral adipose tissue — JAMA· Tesamorelin
  4. [04]FDA approval label — Egrifta· Tesamorelin
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