vialaudit
The Roundup

affiliate disclosure · We earn affiliate commission on some vendor links. Audits, scores, and rankings are independent — vendors do not pay for placement and do not see drafts. read more →

peptide comparison · metabolic × longevity

Cagrilintide vs MOTS-c

Two compounds, mechanism by mechanism. Where they overlap, where they don't, and which vendors stock each.

§ 01

Mechanism

cagrilintide

Cagrilintide

AM833long-acting amylin analog

Synthetic long-acting amylin analog. Activates amylin and calcitonin receptors. Studied in combination with semaglutide as CagriSema in Phase 3 obesity trials.

Full guide →
vs
mots-c

MOTS-c

Mitochondrial-Derived PeptideMOTS

Mitochondrial-derived peptide encoded in the 12S rRNA gene. Activates AMPK signaling and modulates metabolic adaptation. Often described as an exercise-mimetic compound.

Full guide →
§ 02

Key facts

factCagrilintideMOTS-c
category
·metaboliclongevity·
half-life
·~7 daysNot fully characterized; multi-hour systemic effects observed·
research dosing
·Research literature cites 0.16–4.5 mg weekly subcutaneous in dose-escalation studies.Research literature cites 5–15 mg subcutaneous in cycles of 2–8 weeks.·
trending
search demand
○55/10060/100●
vendors stocking
·00·
aliases
·AM833 · long-acting amylin analogMitochondrial-Derived Peptide · MOTS·
§ 03

Use-case overlap

only cagrilintide
  • weight management research
  • amylin-analog studies
  • GLP-1 combination protocols
both

none

only mots-c
  • mitochondrial function
  • exercise-response research
  • metabolic regulation
§ 04

Where to buy

cagrilintide
Cagrilintide
0 verified vendors
See all vendors →
mots-c
MOTS-c
0 verified vendors
See all vendors →
§ 05

Sources

  1. [01]Cagrilintide and semaglutide combination — The Lancet· Cagrilintide
  2. [02]Novo Nordisk CagriSema Phase 3 program· Cagrilintide
  3. [03]The mitochondrial-derived peptide MOTS-c regulates muscle metabolism — Cell Metabolism· MOTS-c
  4. [04]MOTS-c and mitochondrial communication — Trends in Endocrinology· MOTS-c
read next

Other peptide matchups

peptide matchupAOD-9604 vs BPC-157metabolic × healingpeptide matchupAOD-9604 vs Cagrilintidemetabolicpeptide matchupAOD-9604 vs GHK-Cumetabolic × skin
the roundup · monthly

Receipts in your inbox. Once a month.

New audits, expired coupons pruned, lab notes from vials still on the bench. No marketing. No lifestyle copy. Unsubscribe in one click.

14,200 subscribers· 0 sponsored items· 11 issues since launch