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peptide comparison · metabolic

Cagrilintide vs Retatrutide

Two compounds, mechanism by mechanism. Where they overlap, where they don't, and which vendors stock each.

§ 01

Mechanism

cagrilintide

Cagrilintide

AM833long-acting amylin analog

Synthetic long-acting amylin analog. Activates amylin and calcitonin receptors. Studied in combination with semaglutide as CagriSema in Phase 3 obesity trials.

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vs
retatrutide

Retatrutide

LY3437943GLP-3triple-G

Triple agonist of GLP-1, GIP, and glucagon receptors. Eli Lilly's Phase 3 candidate (TRIUMPH program).

Full guide →
§ 02

Key facts

factCagrilintideRetatrutide
category
·metabolicmetabolic·
half-life
·~7 days~6 days·
research dosing
·Research literature cites 0.16–4.5 mg weekly subcutaneous in dose-escalation studies.Research literature cites 1–12 mg weekly subcutaneous in dose-escalation studies.·
trending
search demand
○55/10095/100●
vendors stocking
○06●
aliases
·AM833 · long-acting amylin analogLY3437943 · GLP-3 · triple-G·
§ 03

Use-case overlap

only cagrilintide
  • weight management research
  • amylin-analog studies
  • GLP-1 combination protocols
both

none

only retatrutide
  • weight loss
  • metabolic dysfunction
  • fatty liver
§ 04

Where to buy

cagrilintide
Cagrilintide
0 verified vendors
See all vendors →
retatrutide
Retatrutide
6 verified vendors
Ascension PeptidesLimitless Life NootropicsParadigm PeptidesPeptide Sciences+2 more
See all vendors →
§ 05

Sources

  1. [01]Cagrilintide and semaglutide combination — The Lancet· Cagrilintide
  2. [02]Novo Nordisk CagriSema Phase 3 program· Cagrilintide
  3. [03]Triple–Hormone-Receptor Agonist Retatrutide for Obesity (NEJM)· Retatrutide
  4. [04]Lilly TRIUMPH Phase 3 announcement· Retatrutide
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