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peptide comparison · skin & hair × longevity

GHK-Cu vs MOTS-c

Two compounds, mechanism by mechanism. Where they overlap, where they don't, and which vendors stock each.

§ 01

Mechanism

ghk-cu

GHK-Cu

Copper peptideGlycyl-L-histidyl-L-lysine-Cu

Naturally occurring copper-binding tripeptide. Well-documented in dermatology literature for collagen synthesis and wound healing.

Full guide →
vs
mots-c

MOTS-c

Mitochondrial-Derived PeptideMOTS

Mitochondrial-derived peptide encoded in the 12S rRNA gene. Activates AMPK signaling and modulates metabolic adaptation. Often described as an exercise-mimetic compound.

Full guide →
§ 02

Key facts

factGHK-CuMOTS-c
category
·skin & hairlongevity·
half-life
·—Not fully characterized; multi-hour systemic effects observed·
research dosing
·Topical at 0.05–0.2% concentration; subcutaneous research uses 1–2 mg.Research literature cites 5–15 mg subcutaneous in cycles of 2–8 weeks.·
trending
search demand
●72/10060/100○
vendors stocking
●10○
aliases
·Copper peptide · Glycyl-L-histidyl-L-lysine-CuMitochondrial-Derived Peptide · MOTS·
§ 03

Use-case overlap

only ghk-cu
  • skin regeneration
  • hair growth
  • anti-aging
both

none

only mots-c
  • mitochondrial function
  • exercise-response research
  • metabolic regulation
§ 04

Where to buy

ghk-cu
GHK-Cu
1 verified vendor
Particle Peptides
See all vendors →
mots-c
MOTS-c
0 verified vendors
See all vendors →
§ 05

Sources

  1. [01]GHK Peptide as a Natural Modulator· GHK-Cu
  2. [02]The mitochondrial-derived peptide MOTS-c regulates muscle metabolism — Cell Metabolism· MOTS-c
  3. [03]MOTS-c and mitochondrial communication — Trends in Endocrinology· MOTS-c
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