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peptide comparison · longevity × healing & repair

MOTS-c vs TB-500

Two compounds, mechanism by mechanism. Where they overlap, where they don't, and which vendors stock each.

§ 01

Mechanism

mots-c

MOTS-c

Mitochondrial-Derived PeptideMOTS

Mitochondrial-derived peptide encoded in the 12S rRNA gene. Activates AMPK signaling and modulates metabolic adaptation. Often described as an exercise-mimetic compound.

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vs
tb-500

TB-500

Thymosin Beta-4 fragment

Synthetic fragment of the naturally occurring thymosin beta-4. Researched for cell migration and tissue repair.

Full guide →
§ 02

Key facts

factMOTS-cTB-500
category
·longevityhealing & repair·
half-life
·Not fully characterized; multi-hour systemic effects observed—·
research dosing
·Research literature cites 5–15 mg subcutaneous in cycles of 2–8 weeks.Research literature cites 2–5 mg twice weekly for 4–6 weeks.·
trending
search demand
○60/10068/100●
vendors stocking
○03●
aliases
·Mitochondrial-Derived Peptide · MOTSThymosin Beta-4 fragment·
§ 03

Use-case overlap

only mots-c
  • mitochondrial function
  • exercise-response research
  • metabolic regulation
both

none

only tb-500
  • recovery
  • tissue repair
§ 04

Where to buy

mots-c
MOTS-c
0 verified vendors
See all vendors →
tb-500
TB-500
3 verified vendors
Particle PeptidesPure RawzSwiss Chems
See all vendors →
§ 05

Sources

  1. [01]The mitochondrial-derived peptide MOTS-c regulates muscle metabolism — Cell Metabolism· MOTS-c
  2. [02]MOTS-c and mitochondrial communication — Trends in Endocrinology· MOTS-c
  3. [03]Thymosin beta 4 and its actin-binding partners· TB-500
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