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peptide comparison · longevity × growth

MOTS-c vs Tesamorelin

Two compounds, mechanism by mechanism. Where they overlap, where they don't, and which vendors stock each.

§ 01

Mechanism

mots-c

MOTS-c

Mitochondrial-Derived PeptideMOTS

Mitochondrial-derived peptide encoded in the 12S rRNA gene. Activates AMPK signaling and modulates metabolic adaptation. Often described as an exercise-mimetic compound.

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vs
tesamorelin

Tesamorelin

TH9507Egrifta

Synthetic 44-amino-acid analog of growth hormone-releasing hormone (GHRH). Stimulates pituitary release of endogenous growth hormone in a pulsatile manner.

Full guide →
§ 02

Key facts

factMOTS-cTesamorelin
category
·longevitygrowth·
half-life
·Not fully characterized; multi-hour systemic effects observed~30 minutes (with sustained pituitary effect)·
research dosing
·Research literature cites 5–15 mg subcutaneous in cycles of 2–8 weeks.Research literature cites 1–2 mg daily subcutaneous, typically administered before bed.·
trending
search demand
60/10065/100
vendors stocking
·00·
aliases
·Mitochondrial-Derived Peptide · MOTSTH9507 · Egrifta·
§ 03

Use-case overlap

only mots-c
  • mitochondrial function
  • exercise-response research
  • metabolic regulation
both

none

only tesamorelin
  • visceral fat reduction
  • GHRH analog research
  • HIV-associated lipodystrophy (FDA-approved indication)
§ 04

Where to buy

mots-c
MOTS-c
0 verified vendors
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tesamorelin
Tesamorelin
0 verified vendors
See all vendors →
§ 05

Sources

  1. [01]The mitochondrial-derived peptide MOTS-c regulates muscle metabolism — Cell Metabolism· MOTS-c
  2. [02]MOTS-c and mitochondrial communication — Trends in Endocrinology· MOTS-c
  3. [03]Effects of tesamorelin on visceral adipose tissue — JAMA· Tesamorelin
  4. [04]FDA approval label — Egrifta· Tesamorelin
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