Selank is a synthetic heptapeptide (Thr-Lys-Pro-Arg-Pro-Gly-Pro) derived from the natural peptide tuftsin, developed in Russia and studied for anxiolytic and nootropic effects. In research models it modulates GABAergic signaling, raises BDNF expression, and slows enkephalin breakdown — the basis for interest in anxiety and cognition. It is used clinically in Russia as an intranasal anxiolytic but is not FDA-approved; vendor-sold Selank is research-grade material.
Research notes
How does Selank work?
Selank is a synthetic heptapeptide based on tuftsin, a naturally occurring immunomodulatory peptide. In research models its effects cluster around three mechanisms: modulation of GABAergic tone (the basis for its anxiolytic profile), increased expression of BDNF and other neurotrophic factors, and inhibition of enkephalin-degrading enzymes, which raises endogenous enkephalin levels.
The anxiolytic interest is what distinguishes it from classic nootropics — the research literature reports calming effects without the sedation or dependence associated with benzodiazepines, which is why it is frequently studied as a tuftsin-derived anxiolytic comparator.
What doses are used in research?
Russian clinical literature describes intranasal administration. Research vials are commonly 5–10 mg. Published human studies used intranasal solutions; preclinical work spans routes and doses by model.
What does this guide cover?
Selank is a short, well-characterized sequence, so synthesis is generally straightforward — but identity still has to be confirmed, and the common Semax + Selank blends complicate per-mg comparison. We weight COA-verified identity and single-compound pricing over blend SKUs.
Related reading
What it's researched for
- anxiety research
- cognition and memory models
- neuropeptide signaling
Where to source it
ALL 1 VENDORS →RANKED BY COMPOSITE SCORE · PRICES ARE SNAPSHOTS FROM THE PRICE INDEX · PER-MG IS A WITHIN-COMPOUND COMPARATOR
Frequently asked about Selank
What is Selank?
Selank is a synthetic heptapeptide analog of tuftsin (a fragment of the immunoglobulin G heavy chain). It was developed at the Institute of Molecular Genetics in Russia and is studied for anxiolytic and nootropic activity in research models.
How is Selank different from Semax?
Both are Russian-developed research peptides often studied together, but they derive from different parents and act differently. Selank is a tuftsin analog studied mainly for anxiolytic effects; Semax is an ACTH(4-7) analog studied mainly for neurotrophic/nootropic effects (BDNF). Vendors frequently sell a Semax + Selank blend.
Is Selank FDA-approved?
No. Selank is registered and used as an intranasal anxiolytic in Russia, but it is not approved by the FDA or EMA. Vendor-sold Selank is research-grade, not a medicine.
How do I verify Selank purity?
Look for a per-batch Certificate of Analysis with HPLC purity and mass-spec identity, and run it through our /tools/coa-verifier. A Selank listing with no published COA is unverified.