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The Roundup

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peptide comparison · metabolic

Cagrilintide vs Semaglutide

Two compounds, mechanism by mechanism. Where they overlap, where they don't, and which vendors stock each.

§ 01

Mechanism

cagrilintide

Cagrilintide

AM833long-acting amylin analog

Synthetic long-acting amylin analog. Activates amylin and calcitonin receptors. Studied in combination with semaglutide as CagriSema in Phase 3 obesity trials.

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vs
semaglutide

Semaglutide

OzempicWegovyRybelsus

GLP-1 receptor agonist. FDA-approved as Ozempic (T2D), Wegovy (obesity), and Rybelsus (oral T2D).

Full guide →
§ 02

Key facts

factCagrilintideSemaglutide
category
·metabolicmetabolic·
half-life
·~7 days~7 days·
research dosing
·Research literature cites 0.16–4.5 mg weekly subcutaneous in dose-escalation studies.Research literature cites 0.25–2.4 mg weekly subcutaneous.·
trending
search demand
○55/10082/100●
vendors stocking
○06●
aliases
·AM833 · long-acting amylin analogOzempic · Wegovy · Rybelsus·
§ 03

Use-case overlap

only cagrilintide
  • weight management research
  • amylin-analog studies
  • GLP-1 combination protocols
both

none

only semaglutide
  • weight loss
  • type 2 diabetes
  • cardiovascular risk reduction
§ 04

Where to buy

cagrilintide
Cagrilintide
0 verified vendors
See all vendors →
semaglutide
Semaglutide
6 verified vendors
Amino AsylumAscension PeptidesParadigm PeptidesPeptide Sciences+2 more
See all vendors →
§ 05

Sources

  1. [01]Cagrilintide and semaglutide combination — The Lancet· Cagrilintide
  2. [02]Novo Nordisk CagriSema Phase 3 program· Cagrilintide
  3. [03]Once-Weekly Semaglutide in Adults with Overweight or Obesity (NEJM)· Semaglutide
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