5-Amino-1MQ is a small-molecule inhibitor of the enzyme nicotinamide N-methyltransferase (NNMT) — not actually a peptide, though it is sold throughout the research-peptide market. Inhibiting NNMT raises cellular NAD+ and SAM levels, and in rodent obesity models NNMT blockade is studied for reduced fat mass and increased energy expenditure. It is research-grade only and not approved for any use.
Research notes
How does 5-Amino-1MQ work?
5-Amino-1MQ is a small-molecule inhibitor of NNMT (nicotinamide N-methyltransferase), an enzyme that is over-expressed in white adipose tissue and consumes both NAD+ precursors and S-adenosylmethionine (SAM) when it methylates nicotinamide. Inhibiting NNMT raises intracellular NAD+ and SAM, and in rodent models NNMT knockdown or inhibition is associated with reduced fat mass and increased energy expenditure.
That metabolic mechanism is why it shows up alongside GLP-1 and longevity compounds in vendor catalogs — but it is worth repeating that it is an enzyme inhibitor, not a peptide.
What doses are used in research?
Preclinical studies dose by body weight in rodents. Commercially it is most often sold as oral capsules (e.g. 50 mg) rather than a reconstitutable vial, which is unusual for this market.
What does this guide cover?
Because it is usually a capsule product, per-mg comparison and COA practice work differently than for lyophilized peptides — content/identity assays matter more than a vial-fill figure. We weight whether a vendor publishes a real per-batch analysis at all.
Related reading
What it's researched for
- NNMT inhibition research
- adipose-tissue and metabolic models
- cellular NAD+ / methylation research
Where to source it
ALL 1 VENDORS →RANKED BY COMPOSITE SCORE · PRICES ARE SNAPSHOTS FROM THE PRICE INDEX · PER-MG IS A WITHIN-COMPOUND COMPARATOR
Frequently asked about 5-Amino-1MQ
Is 5-Amino-1MQ a peptide?
No — strictly it is a small-molecule (a methylquinolinium compound), not a peptide. It is grouped with research peptides because it is sold by the same vendors and studied in overlapping metabolic research, but chemically it is an NNMT enzyme inhibitor.
What does 5-Amino-1MQ do in research?
It inhibits nicotinamide N-methyltransferase (NNMT). In preclinical models NNMT inhibition raises NAD+ and S-adenosylmethionine and is studied for effects on adipocyte metabolism, fat mass, and energy expenditure — the basis for metabolic-research interest.
Is 5-Amino-1MQ FDA-approved?
No. It is a research compound with no regulatory approval for human use. Vendor-sold 5-Amino-1MQ is research-grade material.
How is 5-Amino-1MQ sold and verified?
Often as oral capsules (e.g. 50 mg) rather than a lyophilized vial. Verification still rests on a per-batch Certificate of Analysis with purity and identity; run any COA through our /tools/coa-verifier.